Bayside BioSciences Inc
2450 Scott Blvd, Suite 306
Santa Clara, CA 95050
info
Services
- Protein/Antibody Drug Development•Validation of antibody targets (Cell Based Array and Cell Supernatant Array)• Development/engineering/production of protein/antibodies (through partnership with Protevo Biotech)• In vitro characterization of antibodies (cell surface receptor quantification, binding affinity, in vitro efficacy, and cytotoxicity assays)• In vivo evaluation in mouse/rat models (PK, PD, biodistribution, efficacy, and toxicity)• Consultation for scale-up production, and IND regulatory filing
- Small Molecule Drug Development
• Design and implementation of medicinal chemistry programs for lead discovery/optimization (through partnership with DEL Biopharma)
• Preformulation and drug profiling in support of early drug development• In vitro biological evaluations (pathway analysis, cell based HTP screening, cytotoxicity assays)• In vivo toxicity and efficacy evaluation in mouse/rat models• ADME studies in mouse/rat models (in collaboration with bioanalytic groups)• Consultation for formulation development, process optimization, scale-up, and CMC regulatory filing - siRNA Drug Development• Design and selection of potent siRNA via HTP screening• Determination of EC50 of selected lead siRNA API in cultured cells• Confirmation of RNAi mechanism in in vitro and in vivo samples (confirmation of target gene knockdown with qRT-PCR, ELISA/Western blot, and 5’-RACE assays)• In vitro testing of siRNA product (cell-uptake efficiency, cell apoptosis and proliferation assay, and cytotoxicity assays)• Formulation development for in vivo administration (through partnership with Aparna Biosciences and FormuMax Scientific)• In vivo evaluation of siRNA product in mouse/rat models (PK, biodistribution, target gene KD, efficacy, and toxicity)
- Bioanalytic Assays• HPLC (Agilent 1200)• FACS (BD FACSCalibur)• Quantitative RealTime-PCR (ABI 7900)• 5’-RACE (Rapid Amplification of cDNA Ends)• ELISA/Western blot• Fluorescent/luminescence based assay
Copyright 2010 Bayside BioSciences Inc. All rights reserved.
2450 Scott Blvd, Suite 306
Santa Clara, CA 95050
info